| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula(I), wherein V is specified in -O- or a single bond; W is specified in -N(R)C(O)-, -S(O)- and -C(O)O-; X is specified in C(H) or N; Y is specified in S, N(H) or N(CH); p means 0 or 2; t means 1 or 2; Ris specified in a group consisting of hydrogen, Calkyl optionally substituted by 1 or 2 halogroups, CcycloalkylCalkyl, 2,3-dihydro-1H-indenyl, CarCalkyl optionally substituted by one or two halogroups and heteroarylCalkyl, wherein a heteroaryl fragment of the heteroarylalkyl group means 5-6-member monocyclic heteroaryl containing 1 or 2 heteroatoms independently specified in a group consisting of nitrogen optionally oxidated, oxygen and sulphur, or a heteroaryl fragment of the heteroarylalkyl group means 9-member bicyclic heteroaryl containing 1 or 2 heteroatoms independently specified in a group consisting of nitrogen, oxygen and sulphur, wherein monocyclic heteroaryl of the heteroarylalkyl group may be optionally substituted by one or two substitutes independently specified in a group consisting a halogroup, a cyanogroup, Calkyl, haloCalkyl and Calkyl-O-C(O)-; Ris specified in a group consisting of hydrogen, Calkyl optionally substituted by phenoxy, hydroxy Calkyl, Ccycloalkyl, CcycloalkylCalkyl, phenyl optionally substituted by a halogroup, haloCalkyl, CarCalkyl (optionally substituted by a halogroup, haloCalkyl or haloCalkoxygroup), 2-oxo-imidazolidinyl, heterocyclylCalkyl and heteroarylCalkyl, wherein heterocyclyl of heterocyclylalkyl means 5- or 6-member monocycle containing oxygen, and wherein a heteroaryl fragment of the heteroarylalkyl group means 5-6-member monocycle containing 1-3 heteroatoms specified in a group consisting of nitrogen, oxygen and sulphur, or a heteroaryl fragment of the heteroarylalkyl group means 9- or 10-member bicycle containing 1 to 2 heteroatoms specified in a group consisting of nitrogen and sulphur, wherein monocyclic heteroaryl of the heteroaryl alkyl group may be optionally substituted by 1 or 2 substitutes independently specified in a group consisting of a halogroup, Calkyl, haloCalkyl and phenyl optionally substituted by a halogroup; Ris specified in a group consisting of hydrogen and alkyl; two adjacent Rgroups together with carbon atoms whereto attached can form phenyl; Rmeans hydrogen; or a pharmaceutically acceptable salt thereof.EFFECT: preparing the heterocyclic derivatives which modulate activity of stearoyl CoA desaturase, methods of using the above derivatives for modulating activity of stearoyl CoA desaturase and pharmaceutical compositions containing the above derivatives.26 cl, 1 tbl, 153 ex |
