| 摘要 |
<p>The synthetic peptides have the sequence: [RrA/ A2, A6, A8, A11, A12, A15, A20, A21, A22, Nle27, A28, A29, A30]hGH-RH(1 -30)-R2 (SEQ ID NO: 1 ) wherein R1 is Ac, Tfa, or is absent, A1 is Tyr, Dat, or N-Me-Tyr, A2 is Ala, D-Ala, Abu, or D-Abu, A6 is Phe or Fpa5, A8 is Asn, Ala, Gin, Thr, or N-Me-Ala, A11 is Arg, His, or Har, A12 is Orn, or Lys(Me)2, A15 is Abu or Ala A20 is Arg, His, or Har, A21 is Orn, or Lys(Me)2, A22 is Leu, or Orn, A28 is Ser, or Asp, A29 is Arg, Har, Agm, D-Arg, or D-Har, A30 is Arg, Agm, Ada, Amc, Aha, Apa, Har, D-Arg, D-Har, Gab, Gin, D-GIn, Gin-Gab, D-Gln-Gab, or is absent, R2 is -NH2, -OH, -NHR2, -N(R2)2, or -OR2, in which R2 is any of C1-12 alkyl, C2-12 alkenyl, or C2-12 alkinyl, provided that if A29 is Agm then A30 and R2 are absent A1 is N-Me-Tyr only, and pharmaceutically acceptable salts thereof.</p> |
