发明名称 |
FLUOROALKYLATION METHODS AND REAGENTS |
摘要 |
A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1. |
申请公布号 |
EP2606048(A1) |
申请公布日期 |
2013.06.26 |
申请号 |
EP20110818823 |
申请日期 |
2011.08.19 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
HARTWIG, JOHN, F.;MORIMOTO, HIROYUKI;FIER, PATRICK |
分类号 |
C07D471/04;C07C29/32;C07C41/30;C07C45/68 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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