发明名称 |
USE OF N-HYDROXYSUCCINIMIDE TO IMPROVE CONJUGATE STABILITY |
摘要 |
<p>The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability in the presence of exogenous NHS. In some embodiments, the inventive process comprises the addition of a molar ratio of exogenous NHS with respect to the amount of NHS generated during the modification reaction as a result of hydrolysis/aminolysis of the bifunctional linker.</p> |
申请公布号 |
WO2013090590(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
WO2012US69527 |
申请日期 |
2012.12.13 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
LIU, FANG;AMPHLETT, GODFREY W.;MESHULAM, DEBORAH H. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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