COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS
摘要
The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.
申请公布号
WO2013086436(A1)
申请公布日期
2013.06.13
申请号
WO2012US68599
申请日期
2012.12.07
申请人
FRED HUTCHINSON CANCER RESEARCH CENTER;NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC.,DBA THE GENOMICS INSTITUTE OF THE NORVATIS RESEARCH FOUNDATION (GNF)
发明人
BERNSTEIN, IRWIN, D.;BOITANO, ANTHONY, E.;COOKE, MICHAEL