发明名称 |
HERPES SIMPLEX VIRUS (HSV) WITH MODIFIED TROPISM, USES AND PROCESS OF PREPARATION THEREOF |
摘要 |
A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed. |
申请公布号 |
EP2293804(B1) |
申请公布日期 |
2013.05.22 |
申请号 |
EP20080789969 |
申请日期 |
2008.05.29 |
申请人 |
ALMA MATER STUDIORUM -UNIVERSITA' DI BOLOGNA |
发明人 |
CAMPADELLI, GABRIELLA;MENOTTI, LAURA |
分类号 |
C12N7/00;C07K14/00;C07K14/005 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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