AMINE-LINKED PYRIDYL AND PHENYL SUBSTITUTED PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY

摘要

The present application discloses a compound, or enantiomers, stereoisomers,
rotamers, tautomers, racemates or prodrug of said compound, or
pharmaceutically acceptable salts, solvates or esters of said compound, or of
said prodrug, said compound having the general structure shown in Formula 1:
Chemical formual should be inserted here as it appears on the abstract in
paper form. and the pharmaceutically acceptable salts, solvates and esters
thereof. Also disclosed is a method of treating chemokine mediated diseases,
such as, palliative therapy, curative therapy, prophylactic therapy of certain
diseases and conditions such as inflammatory diseases (non limiting example(s)
include, psoriasis), autoimmune diseases (non limiting example(s) include,
rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting
example(s) include, allograft rejection, xenograft rejection), infectious
diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-
type hypersensitivity responses, ophthalmic inflammation, type I diabetes,
viral meningitis and tumors using a compound of Formula 1.