发明名称 |
Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals |
摘要 |
The present invention relates to compositions and methods for preparing radiopharmaceutical compounds in high chemical-purity and isotopic-purity. The present invention provides polymer-bound precursors to radiopharmaceutical compounds that can be converted to radiopharmaceutical compounds in one step. In a preferred embodiment, a radiopharmaceutical precursor is bound to a polymeric support via a prosthetic group comprising an alkenyl-tin bond. The radiopharmaceutical precursor is converted to a radiopharmaceutical compound in one step involving cleavage of the alkenyl-tin bond and incorporation of a radioisotope to form the radiopharmaceutical compound. Importantly, the polymeric support containing the toxic tin by-product can be easily removed from the radiopharmaceutical compound by filtration. The present invention can be used to install a large number of different radioisotopes. In a preferred embodiment, the radioisotope is 211At, 123I or 131I. |
申请公布号 |
US8435492(B2) |
申请公布日期 |
2013.05.07 |
申请号 |
US20040555248 |
申请日期 |
2004.04.30 |
申请人 |
HUNTER DUNCAN;GAGNON M. KAREN J.;UNIVERSITY OF WESTERN ONTARIO |
发明人 |
HUNTER DUNCAN;GAGNON M. KAREN J. |
分类号 |
A61K51/00;A61K51/04;C07B59/00;C07F7/22 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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