发明名称 |
Cytotoxic benzodiazepine derivatives |
摘要 |
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. |
申请公布号 |
AU2012231640(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
AU20120231640 |
申请日期 |
2012.02.15 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
LI, WEI;MILLER, MICHAEL;FISHKIN, NATHAN;CHARI, RAVI V. J. |
分类号 |
C07D487/04;A61K47/48;A61P35/00;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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