发明名称 |
Recombinant Adenovirus Having Anti-Angiogenesis Activity |
摘要 |
The present disclosure relates to a recombinant adenovirus with improved angiogenesis inhibition activity and a pharmaceutical composition for inhibiting angiogenesis. The recombinant adenovirus includes: (a) an inverted terminal repeat (ITR) nucleotide sequence of an adenovirus; and (b) a nucleotide sequence coding for a chimeric decoy receptor containing (i) an extracellular domain of vascular endothelial growth factor receptor 1 (VEGFR-1) and (ii) an extracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2). The recombinant adenovirus according the present disclosure which expresses the chimeric decoy receptor inhibits angiogenesis very effectively and can be used for gene therapy for various angiogenesis-related diseases. Particularly, the recombinant adenovirus of the present disclosure has superior oncolytic activity.
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申请公布号 |
US2013101557(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201013519934 |
申请日期 |
2010.11.09 |
申请人 |
YUN CHAE OK;INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY |
发明人 |
YUN CHAE OK |
分类号 |
A61K35/76;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P9/08;A61P9/10;A61P13/12;A61P17/02;A61P17/06;A61P19/02;A61P19/08;A61P25/00;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P37/06;C12N7/01 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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