The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
申请公布号
AU2011295792(A1)
申请公布日期
2013.04.18
申请号
AU20110295792
申请日期
2011.09.02
申请人
THE SCRIPPS RESEARCH INSTITUTE
发明人
REISFELD, RALPH A.;XIANG, RONG;LUO, YUNPING;LIAO, DEBBIE;LIU, ZE;CHEN, TINGMEI;CHEN, SI;LU, DAN