发明名称 |
Chimeric protein for prevention and treatment of HIV infection |
摘要 |
This invention relates to bispecific fusion proteins effective in viral neutralization. More specifically, such proteins have two different binding domains, an inducing-binding domain and an induced-binding domain, functionally linked by a peptide linker. Such proteins, nucleic acid molecules encoding them, and their production and use in preventing or treating viral infections are provided. One prototypical bispecific fusion protein is sCD4-SCFv(17b), in which a soluble CD4 fragment (containing domains D1 and D2) is fused to a single chain Fv portion of antibody 17b via a linker.
|
申请公布号 |
US8420099(B2) |
申请公布日期 |
2013.04.16 |
申请号 |
US20060535957 |
申请日期 |
2006.09.27 |
申请人 |
BERGER EDWARD A.;DEL CASTILLO CHRISTIE M.;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BERGER EDWARD A.;DEL CASTILLO CHRISTIE M. |
分类号 |
A61K39/21;C07H21/02;C07H21/04;C07K14/00;C07K16/08;C07K16/42 |
主分类号 |
A61K39/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|