| 摘要 |
<p>Provided are: a hemoglobin-containing liposome which has a secured high hemoglobin encapsulation ratio, excellent physical stability and excellent stability in a living organism, and also has a specific membrane composition; and a method for producing the hemoglobin-containing liposome. A hemoglobin-containing liposome, in which a hemoglobin solution is contained as an internal fluid of the liposome, the membrane of the liposome is composed of a mixed lipid comprising a phospholipid, cholesterol and a higher saturated fatty acid, the molar ratio of the cholesterol to the phospholipid (cholesterol/phospholipid) is 0.7-1.0, and the content of stearic acid in the mixed lipid is 25-30 mol%. Preferably, the membrane of the liposome additionally contains a polyethylene-glycol-binding phospholipid in an amount of 0.8 mol% or more relative to the total amount of the membrane-constituting lipid, and the polyethylene-glycol-binding phospholipid is bound to the outer surface of the membrane.</p> |
