摘要 |
A bone biospecific agent 2 is disclosed comprising a contrast material core 4, which is visible using Magnetic Resonance Imaging (MRI) or Computed Tomography (CT). The contrast material core is surrounded by a polymeric shell 6, which is functionalised with a bone targeting peptide 8. In use, the peptide 8 targets the biospecific agent 2 to bone. The bone biospecific agent can be used in diagnostic imaging techniques, such as MRI and CT, and in imaging bone remodelling activities, detecting and treating pathological bone conditions and/or bone repair processes. The invention extends to the diagnosis and/or treatment of bone disease and bone pathologies using the biospecific agents. The bone targeting peptide may comprise an amino acid sequence which mimics osteoprogeterin (OPG). |