| 发明名称 |
A PAMAM DENDRIMER DERIVATIVES FOR NEUCLEOTIDE DELIVERY |
| 摘要 |
<p>PURPOSE: A PAMAM(polyamidoamine) derivative for nucleic acid delivery is provided to improve a buffering capacity and transfection efficiency without cytotoxicity. CONSTITUTION: A PAMAM derivative for nucleic acid delivery contains PAMAM, histidine, and a cationic compound. The cationic compound is lysine, arginine, or guanidine. The surface of PAMAM is grafted with the cationic compound which is conjugated with a histidine residue. PAMAM is a dendrite type dendrimer.</p> |
| 申请公布号 |
KR20130024326(A) |
申请公布日期 |
2013.03.08 |
| 申请号 |
KR20110087711 |
申请日期 |
2011.08.31 |
| 申请人 |
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) |
发明人 |
CHOI, JOON SIG;YU, GWANG SIG;BAE, YUN MI |
| 分类号 |
C12N15/87;C12N15/63;C12Q1/68 |
主分类号 |
C12N15/87 |
| 代理机构 |
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