| 发明名称 |
MODIFIED STREPTOCOCCUS PNEUMONIAE PNEUMOLYSIN (PLY) POLYPEPTIDES |
| 摘要 |
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided. |
| 申请公布号 |
EP2376526(A4) |
申请公布日期 |
2013.02.27 |
| 申请号 |
EP20090833971 |
申请日期 |
2009.12.22 |
| 申请人 |
KINGDOM OF THE NETHERLANDS, REPRESENTED BY THE MIN ISTER OF HEALTH, WELFARE & SPORT, ON BEHALF OF THE MINISTER, NAT.INST. OF PUBLIC HEALTH & THE ENV. |
发明人 |
OLOO, ELIUD;OOMEN, RAYMOND;OCHS-ONOLEMHEMHEN, MARTINA;YETHON, JEREMY |
| 分类号 |
C07K14/315;A61K39/09;A61P31/04;C07K16/12;C12N15/31 |
主分类号 |
C07K14/315 |
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