发明名称 |
ACTIVITY BASED PROBES (ABPs) INTERACTING WITH GLYCOSIDASES |
摘要 |
An activity based probe (ABP) comprising a glycosidase inhibitor, and a detection-group. The ABPs of the inventions are used for diagnosing storage disorder for screening of compounds suitable for preventing and/or treating a storage disorder, for monitoring of therapeutic enzymes for lysosomal storage disorders, and for ultra-sensitive visualization of glycosidase-fusion proteins in molecular imaging. |
申请公布号 |
EP2545184(A1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20110712027 |
申请日期 |
2011.03.10 |
申请人 |
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM;UNIVERSITEIT LEIDEN |
发明人 |
AERTS, JOHANNES MARIA FRANCISCUS GERARDUS;OVERKLEEFT, HERMAN STEVEN |
分类号 |
C12Q1/34;C07K1/13;G01N33/68 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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