摘要 |
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
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申请人 |
TIBOTEC PHARMACEUTICALS LTD.;MEDIVIR AB;SIMMEN KENNETH ALAN;DE KOCK HERMAN AUGUSTINUS;RABOISSON PIERRE JEAN-MARIE BERNARD;HU LILI;TAHRI ABDELLAH;SURLERAUX DOMINIQUE LOUIS NESTOR GHISLAIN;NILSSON KARL MAGNUS;SAMUELSSON BENGT BERTIL;ROSENQUIST AASA ANNICA KRISTINA;IVANOV VLADIMIR;PELCMAN MIKAEL;BELFRAGE ANNA KARIN GERTRUD LINEA;JOHANSSON PER-OLA MIKAEL;VENDEVILLE SANDRINE MARIE HELENE |
发明人 |
SIMMEN KENNETH ALAN;DE KOCK HERMAN AUGUSTINUS;RABOISSON PIERRE JEAN-MARIE BERNARD;HU LILI;TAHRI ABDELLAH;SURLERAUX DOMINIQUE LOUIS NESTOR GHISLAIN;NILSSON KARL MAGNUS;SAMUELSSON BENGT BERTIL;ROSENQUIST AASA ANNICA KRISTINA;IVANOV VLADIMIR;PELCMAN MIKAEL;BELFRAGE ANNA KARIN GERTRUD LINEA;JOHANSSON PER-OLA MIKAEL;VENDEVILLE SANDRINE MARIE HELENE |