发明名称 |
RADIOLABELED AFFIBODY MOLECULES |
摘要 |
The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.
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申请公布号 |
US2013004421(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
US201213608054 |
申请日期 |
2012.09.10 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVICES;CAPALA JACEK;KIESEWETTER DALE O.;KRAMER-MAREK GABRIELA;LEE SANG BONG |
发明人 |
CAPALA JACEK;KIESEWETTER DALE O.;KRAMER-MAREK GABRIELA;LEE SANG BONG |
分类号 |
C07K14/31;A61K51/10 |
主分类号 |
C07K14/31 |
代理机构 |
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