LOX AND LOXL2 INHIBITORS ANTIBODIES AND USES THEREOF
摘要
The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.
申请公布号
EP2537529(A1)
申请公布日期
2012.12.26
申请号
EP20120172222
申请日期
2008.08.01
申请人
GILEAD BIOLOGICS, INC.
发明人
SMITH, VICTORIA;GARCIA, CARLOS AURELIO;BIERMANN, DONNA HIROKO TOKUOKA;OGG, SCOTT;VAN VLASSELAER, PETER;BARRY, VIVIAN E.;MARSHALL, DEREK;HOLZER, ALISON KAY;RODRIGUEZ, HECTOR;OYASU, MIHO;MCCAULEY, SCOTT ALAN