发明名称 1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
摘要 The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.
申请公布号 US8338461(B2) 申请公布日期 2012.12.25
申请号 US201113037690 申请日期 2011.03.01
申请人 KAJINO MASAHIRO;HASUOKA ATSUSHI;NISHIDA HARUYUKI;TAKEDA PHARMACEUTICAL COMPANY LIMITED 发明人 KAJINO MASAHIRO;HASUOKA ATSUSHI;NISHIDA HARUYUKI
分类号 C07D401/02;A61K31/444 主分类号 C07D401/02
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