发明名称 |
APTAMER FOR CHYMASE, AND USE THEREOF |
摘要 |
<p>Disclosed is an aptamer that specifically binds to chymase to inhibit a chymase activity. Also disclosed is a complex comprising said aptamer and a functional substance (i.e., an affinity substance, a substance for labelling, an enzyme, a drug delivery vehicle or a drug). Further disclosed is the use of said aptamer in the manufacture of a medicament for use in the prevention of treatment of a cardiovascular disease or fibrosis. Also disclosed is a method of detecting or purifying a chymase using said aptamer or complex.</p> |
申请公布号 |
NZ597269(A) |
申请公布日期 |
2012.12.21 |
申请号 |
NZ20100597269 |
申请日期 |
2010.06.11 |
申请人 |
OTSUKA PHARMACEUTICAL CO. LTD.;RIBOMIC INC. |
发明人 |
NAKAMURA, YOSHIKAZU;JIN, LING;YAMAZAKI, SATOKO;IKEDA, HISAKO;MURAGUCHI, MASAHIRO |
分类号 |
A61P19/04;A61P9/00;A61P43/00;C12N15/09;C12Q1/68 |
主分类号 |
A61P19/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|