发明名称 |
1-aryl- or 1-heteroaryl-pyrido[B]indoles and uses thereof in treating cancers |
摘要 |
Provided herein are 1-aryl or 1-heteroaryl pyrido[b]indoles compounds with the structure These compounds comprise a &bgr;-carboline ring structure substituted at C1 with an aryl or heteroaryl moiety and individually substituted at C3-C8 and N9 with a C1-C4 alkyl, a C1-C4 alkoxy, a C1-C4 alkoxyphenyl, or a hydrogen. Also provided are methods for inhibiting proliferation of cancer cells or for treating a cell proliferative disease by contacting the cancer cell or tumor comprising the same with the compounds provided herein or by administering the compounds to a subject with a cell proliferative disease. |
申请公布号 |
US8329723(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20100799485 |
申请日期 |
2010.04.26 |
申请人 |
BUOLAMWINI JOHN K;PATIL SHRIVAPUTRA;HORRICK SHARMA;ADDO JAMES K |
发明人 |
BUOLAMWINI JOHN K;PATIL SHRIVAPUTRA;HORRICK SHARMA;ADDO JAMES K |
分类号 |
A61K31/44 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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