| 摘要 |
FIELD: chemistry.SUBSTANCE: present invention relates to dihydropyrazolone derivativesorof formula(I), where Rdenotes a heteroaryl group of formulae given below, where * denotes the linkage point with the dihydropyrazolone ring, A in each individual occurrence denotes C-Ror N, wherein at most two ring members A represent N at the same time, E denotes O or S, R, Rand Rare as defined in the claim. The invention also relates to a method of producing said compounds.EFFECT: compounds of formula (I) inhibit HIF-propylhydroxylase activity and can be used to treat and/or prevent diseases, as well as for producing medicaments for treating and/or preventing diseases, particularly cardiovascular and haematologic diseases, kidney diseases, and for promoting the healing of wounds.10 cl, 10 tbl, 178 ex |
