发明名称 |
Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus |
摘要 |
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The rlated conjugates can target specific cell types to provide therapeutic benefit. |
申请公布号 |
AU2006269422(B2) |
申请公布日期 |
2012.12.06 |
申请号 |
AU20060269422 |
申请日期 |
2006.07.07 |
申请人 |
SEATTLE GENETICS, INC. |
发明人 |
DORONINA, SVETLANA O.;KLINE, TONI BETH |
分类号 |
C07K7/00;A61K38/00 |
主分类号 |
C07K7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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