发明名称 |
ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS |
摘要 |
The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7- O -malonyl macrolactin A and 7- O -succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-±), interleukin-1² (IL-1²), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines. Therefore, the macrolactin compounds produced by the Bacillus polyfermenticus KJS-2 strain according to the present invention can provide excellent anti-inflammatory agents. |
申请公布号 |
EP2433631(A4) |
申请公布日期 |
2012.10.24 |
申请号 |
EP20100777977 |
申请日期 |
2010.05.24 |
申请人 |
DAEWOO PHARMACEUTICAL IND. CO., LTD. |
发明人 |
JI, YOUNG-HOON;KIM, DONG-HEE;KANG, JAE-SEON;KIM, CHUN-GYU;CHUNG, SUNG-UK;HWANG, SUNG-WOO;KANG, KYUNG-RAN |
分类号 |
A61K31/335;A61P29/00 |
主分类号 |
A61K31/335 |
代理机构 |
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