| 发明名称 |
EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION |
| 摘要 |
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites. |
| 申请公布号 |
US2012252681(A1) |
申请公布日期 |
2012.10.04 |
| 申请号 |
US201113310332 |
申请日期 |
2011.12.02 |
| 申请人 |
DEL CARDAYRE STEPHEN;TOBIN MATTHEW;STEMMER WILLEM P.C.;NESS JON E.;MINSHULL JEREMY;PATTEN PHILLIP;SUBRAMANIAN VENKITESWARAN;CASTLE LINDA A.;KREBBER CLAUS M.;BASS STEVEN H.;ZHANG YING-XIN;COX TONY;HUISMAN GJALT;YUAN LING;AFFHOLTER JOSEPH A.;CODEXIS MAYFLOWER HOLDINGS, LLC |
发明人 |
DEL CARDAYRE STEPHEN;TOBIN MATTHEW;STEMMER WILLEM P.C.;NESS JON E.;MINSHULL JEREMY;PATTEN PHILLIP;SUBRAMANIAN VENKITESWARAN;CASTLE LINDA A.;KREBBER CLAUS M.;BASS STEVEN H.;ZHANG YING-XIN;COX TONY;HUISMAN GJALT;YUAN LING;AFFHOLTER JOSEPH A. |
| 分类号 |
A01H5/00;C40B10/00;A01K67/027;C07K14/245;C12N15/09;C12N15/10;C12N15/82;C12P17/16;C12Q1/68 |
主分类号 |
A01H5/00 |
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