发明名称 |
HGF precursor protein variant and active protein thereof |
摘要 |
An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a &bgr; chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the &bgr; chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action. |
申请公布号 |
US8278270(B2) |
申请公布日期 |
2012.10.02 |
申请号 |
US201113175110 |
申请日期 |
2011.07.01 |
申请人 |
NAKAMURA TOSHIKAZU;MATSUMOTO KUNIO;FUKUTA KAZUHIRO;ADACHI KIICHI;HAYATA DAICHIKA;KRINGLE PHARMA INC.;OSAKA UNIVERSITY |
发明人 |
NAKAMURA TOSHIKAZU;MATSUMOTO KUNIO;FUKUTA KAZUHIRO;ADACHI KIICHI;HAYATA DAICHIKA |
分类号 |
A61K38/18;C07K14/475;C12N5/00;C12N15/00;C12P21/04;C12P21/06 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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