发明名称 |
BRIDGED ARTIFICIAL NUCLEOSIDE AND NUCLEOTIDE |
摘要 |
It is an object of the present invention to provide a novel molecule for antisense therapies which is not susceptible to nuclease degradation in vivo and has a high binding affinity and specificity for the target mRNAs and which can efficiently regulate expression of specific genes. The novel artificial nucleosides of the present invention has an amide bond introduced into a bridge structure of 2', 4' -BNA/LNA. The oligonucleotide containing the 2', 4' -bridged artificial nucleotide has a binding affinity for a single-stranded RNA comparable to known 2', 4' -BNA/LNA and has an increased nuclease resistance over LNA. Particularly, it is expected to be applied to nucleic acid drugs because of its much stronger binding affinity for single-stranded RNAs than S-oligo's affinity |
申请公布号 |
EP2495248(A1) |
申请公布日期 |
2012.09.05 |
申请号 |
EP20100826568 |
申请日期 |
2010.10.19 |
申请人 |
OSAKA UNIVERSITY |
发明人 |
OBIKA, SATOSHI;HARI, YOSHIYUKI;KODAMA, TETSUYA;YAHARA, AIKO;NISHIDA, MASARU |
分类号 |
C07H19/06;A61K9/00;A61K9/06;A61K31/712;A61K47/42;C07H19/073;C07H19/16;C07H19/173;C07H21/00;C07H23/00;C12N15/09;C12N15/11;C12N15/113 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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