发明名称 |
In vivo HCV resistance to anti-viral inhibitors |
摘要 |
<p>HCV mutations emerged in chimpanzees treated with a N5B polymerase inhibitor (Compound A) or a NS3 protease inhibitor (Compound B). Short term treatment with Compound A was followed by the initial emergence of an HCV with a S282T polymerase mutation following treatment. Short term treatment with Compound B selected for HCV with a R155K or D168T protease mutation.</p> |
申请公布号 |
EP2481807(A2) |
申请公布日期 |
2012.08.01 |
申请号 |
EP20120157803 |
申请日期 |
2008.03.05 |
申请人 |
MERCK SHARP & DOHME CORPORATION |
发明人 |
LUDMERER, STEVEN. W.;GRAHAM, DONALD J.;OLSEN, DAVID B.;GLAAB, WARREN E. |
分类号 |
C12Q1/00;C07H21/00;C12Q1/68;C12Q1/70 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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