| 摘要 |
<p>A continuous process for preparing microcapsules containing water-insoluble active principle, for use in the pharmaceutical and agrochemical field, comprising:
(1) preparation in a first reactor under stirring of an aqueous solution containing one or more surfactants,
(2) preparation in a second reactor under stirring of a solution comprising at least an active principle immiscible in an aqueous phase and the first component for preparing the polycondensation polymer forming the microcapsule shell,
simultaneous feeding to a tubular reactor of a stream of the aqueous solution (1) and of a stream of solution (2), being the ratio stream solution (2)/stream solution (1) comprised between 0.5 and 2.0,
then optionally in a time of 0-10 seconds, inlet into the reactor of a stream (3) of the second component for preparing the polycondensation polymer, that reacts with the first component,
streams (1),(2) and (3) being under turbulent flow conditions in the tubular reactor,
the ratio between the equivalents of the first component and the equivalents of the second component are comprised between 0.9 and 1.1,
streams (1), (2) and (3) being continuously fed to the tubular reactor.</p> |
