发明名称 |
COMPOUNDS AND RELATED METHODS FOR MANIPULATING PARP-1-DEPENDENT CELL DEATH |
摘要 |
Apoptosis inducing factor ("AIF") contains a PAR-binding motif ("PBM") that binds to Poly(ADP-ribose) ("PAR"). Binding of PAR to AIF via the PBM is required for AIF release from the mitochondria to occur, and that this PAR-related release is a key step in the programmed cell death process known as parthanatos, both in vitro and in vivo. Preventing or disrupting this release can inhibit parthanatos and thus be the basis for treatments for patients suffering from diseases or medical conditions during which parthanatos commonly occurs, including Parkinson's disease or diabetes, or patients who have had and are recovering from heart attack, stroke and other ischemia reperfusion-related injuries. Alternatively, agents could be identified that enhance the release of AIF, thereby promoting parthanatos and serving as potential anti-tumor chemotherapeutic agents. |
申请公布号 |
WO2012065106(A3) |
申请公布日期 |
2012.07.19 |
申请号 |
WO2011US60439 |
申请日期 |
2011.11.11 |
申请人 |
DAWSON, TED M.;DAWSON, VALINA L.;WANG, YINGFEI |
发明人 |
DAWSON, TED M.;DAWSON, VALINA L.;WANG, YINGFEI |
分类号 |
A61K38/17;A61P1/00;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P13/12;A61P19/02;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P35/00;C07K14/435;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/63;C12P21/02;C12Q1/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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