发明名称 |
NOVEL PROCESS FOR THE SYNTHESIS OF PEMETREXED DISODIUM SALT |
摘要 |
The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2. |
申请公布号 |
US2012172595(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
US201113176199 |
申请日期 |
2011.07.05 |
申请人 |
CIAMBECCHINI UMBERTO;TURCHETTA STEFANO;ZENONI MAURIZIO;DE FERRA LORENZO;BRANDI PAOLO;CHEMI S.P.A. |
发明人 |
CIAMBECCHINI UMBERTO;TURCHETTA STEFANO;ZENONI MAURIZIO;DE FERRA LORENZO;BRANDI PAOLO |
分类号 |
C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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