发明名称 |
DNA VACCINES ENCODING HEAT SHOCK PROTEINS |
摘要 |
The present invention is related to recombinant constructs encoding heat shock proteins or active fragments thereof, effective in treating T cell mediated inflammatory autoimmune diseases by DNA vaccines. The treatment with the recombinant constructs of the present invention provides long-term expression of specific heat shock proteins for fragments thereof. In one embodiment, the present invention is related to a recombinant construct comprising a nucleic acid sequence encoding HSP60, HSP70 or HSP90. In various preferred embodiments, the present invention is related to a recombinant construct comprising a nucleic acid sequence selected from amino acids 1-140 of HSP60, amino acids 130-260 of HSP60 and amino acids 31-50 of HSP60. Another aspect of the present invention is related to an active fragment of HSP60 corresponding to amino acids 31-50 of HSP60 effective in treating arthritis. |
申请公布号 |
EP1575526(B1) |
申请公布日期 |
2012.06.06 |
申请号 |
EP20030723033 |
申请日期 |
2003.05.21 |
申请人 |
COHEN, IRUN R.;QUINTANA, FRANCISCO JAVIER;CARMI, PNINA;MOR, FELIX |
发明人 |
COHEN, IRUN R.;QUINTANA, FRANCISCO JAVIER;CARMI, PNINA;MOR, FELIX |
分类号 |
A61K39/00;A61K;A61K31/7088;A61K38/17;A61K48/00;A61P37/06 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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