MIXED METAL COMPOUNDS FOR TREATMENT OF HYPERPHOS PHATAEMIA

摘要

Disclosed are mixed metal compounds of formula (III) MIl1-aMIIla(OH)dAn-c.ZH20 (III) wherein MIl is at least Mg (II); MIll is at least one trivalent metal selected from AI(III), Mn(III), Fe(III), La(III) and Ce(III); An- is at least one n-valent anion and wherein at least one anion is carbonate; 1>a>0.7; Wherein the mixed metal compound comprises less than 15 percent water soluble salts by weight of the mixed metal compound after drying. Also disclosed are pharmaceutical compositions comprising the mixed metal compounds as well as the use of the mixed metal compounds for binding phosphate and for treating hyperphosphataemia, metabolic bone disease, metabolic syndrome, renal insufficiency, hypoparathyroidism, pseudohypoparathyroidism, acute untreated acromegaly, chronic kidney disease (CKD), severe bone problems, soft tissue calcification, secondary hyperparathyroidism, over medication of phosphate salts and other conditions requiring control of phosphate absorption.