发明名称 |
Cell Cycle Arrest and Apoptosis |
摘要 |
The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1-induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4.sup.+ lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-1 (BRCA1). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr. |
申请公布号 |
US2012122770(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
US201113175912 |
申请日期 |
2011.07.04 |
申请人 |
PLANELLES VICENTE;ANDERSEN JOSHUA L.;ZIMMERMAN ERIK |
发明人 |
PLANELLES VICENTE;ANDERSEN JOSHUA L.;ZIMMERMAN ERIK |
分类号 |
A61K38/16;A61P3/04;A61P43/00;C07K19/00;C12N5/071;C12N15/113;C40B30/04 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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