PHOSPHORAMIDATE DERIVATIZATION OF INORGANIC POLYPHOSPHATES AND METHODS

摘要

Provided are methods for making phosphoramidate-modified polyphosphate molecules using a reactant with a primary amine group and polyphosphate (optionally in the presence of divalent cations), in the presence of a zero-length linking group, where the modifying moiety is linked via the nitrogen of a primary amine group to a terminal phosphorus of a polyphosphate moiety. The phosphoramidate derivatized polyphosphate molecules are useful in methods to stimulate or accelerate coagulation in a human or animal subject where there is coagulation deficiency due to medication or genetic deficiency and/or where there is trauma, surgery or other event or risk of bleeding, and to inhibit tumor growth, survival or angiogenesis in a patient in need thereof.