发明名称 |
USE OF LAG-3 AS AN MHC CLASS II LIGAND IN COMBINATION WITH AN ANTIGEN FOR THE MANUFACTURE OF A MEDICAMENT FOR AMPLIFYING A CELL RESPONSE TO AN ANTIGEN |
摘要 |
The present invention concerns a use of a MHC class II ligand, such as CD4 and LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune response, as well as the use of LAG-3 in cancer-immunotherapy. The invention also concerns a pharmaceutical composition comprising an effective amount of an antigen able to induce an antigen-specific immune response together with an effective amount of MHC class II ligand wherein said MHC class II ligand is present as an adjuvant-like agent. |
申请公布号 |
IL134212(A) |
申请公布日期 |
2012.03.29 |
申请号 |
IL20000134212 |
申请日期 |
2000.01.24 |
申请人 |
INSTITUT GUSTAVE ROUSSY;MERCK SERONO S.A.;APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
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分类号 |
A61K48/00;A61K38/00;A61K38/17;A61K39/00;A61K39/39;A61M36/14;A61P31/04;A61P31/12;A61P33/10;A61P35/00;A61P37/02;C12N5/08;C12N5/10;C12N15/63 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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