MODEL ANIMAL FOR STUDYING HAIR GROWTH CYCLE

摘要

The present invention provides a non-human animal wherein FGF18 expression is selectively inhibited in hair follicles, thus shortening the telogen phase of the hair growth cycle, by producing a non-human model animal wherein the Fgf18 gene has been selectively knocked out in keratin 5-positive cells using a Cre-loxP system. The non-human model animal is useful for studying hair follicles and skin, particularly for studying hair growth that arises cyclically at the hair follicle cells, and can be utilized in developing and screening novel drugs against hair follicle and skin disorders.