发明名称 |
Substituted benzoazepines as Toll-like receptor modulators |
摘要 |
Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease. |
申请公布号 |
AU2010284241(A1) |
申请公布日期 |
2012.03.08 |
申请号 |
AU20100284241 |
申请日期 |
2010.08.18 |
申请人 |
ARRAY BIOPHARMA, INC;VENTIRX PHARMACEUTICALS, INC. |
发明人 |
HOWBERT, JAMES JEFFRY;DIETSCH, GREGORY;HERSHBERG, ROBERT;BURGESS, LAURENCE E.;DOHERTY, GEORGE A.;EARY, C. TODD;GRONEBERG, ROBERT D.;JONES, ZACHARY |
分类号 |
C07D403/10;A61K31/4025;A61K31/55;A61P31/00;A61P35/00;C07D223/14;C07D401/14;C07D403/14 |
主分类号 |
C07D403/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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