| 发明名称 |
STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER |
| 摘要 |
An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer. |
| 申请公布号 |
EP2424499(A1) |
申请公布日期 |
2012.03.07 |
| 申请号 |
EP20100717961 |
申请日期 |
2010.04.30 |
| 申请人 |
ABBOTT LABORATORIES |
发明人 |
CATRON, NATHANIEL;FICKES, MICHAEL;FISCHER, CRISTINA;HAIGHT, ANTHONY R.;HEEMSTRA, KATHERINE;SANZGIRI, YESHWANT;SCHMITT, ERIC;TONG, PING;ZHANG, GEOFF;ZHOU, DELIANG |
| 分类号 |
A61K9/00;A61K9/48;A61K31/5377;A61K47/00;A61K47/02;A61K47/14;A61K47/20 |
主分类号 |
A61K9/00 |
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