发明名称 |
PRETARGETING KIT, METHOD AND AGENTS USED THEREIN |
摘要 |
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne. |
申请公布号 |
EP2419142(A2) |
申请公布日期 |
2012.02.22 |
申请号 |
EP20100717257 |
申请日期 |
2010.04.12 |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N.V. |
发明人 |
ROBILLARD, MARC, S.;ROSSIN, RAFFAELLA;LUB, JOHAN;RENART VERKERK, PASCAL;BURDINSKI, DIRK |
分类号 |
A61K47/48;A61K51/04 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|