METHOD OF OBTAINING CARBAMIDE LABELLED BY STABLE ISOTOPE 13C

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to method of obtaining carbamide with stable carbon isotope 13C for application in medical diagnostics of gastrointestinal tract diseases. Claimed method has two stages, the first stage includes interaction of labeled carbon dioxide and propylene oxide at temperature 120-130C and pressure 1.3-1.5 MPa in presence of catalyst with further isolation of labeled propylene carbonate. Catalyst of the first stage is complex of zinc bromide with tertiary organophosphine or 1-butyl-3-methylimidasolium chloride, and mole ratio of propylene oxide to catalyst constitutes 500-2000:1. At the second stage carried out is ammonolysis of isolated liquid propylene carbonate at temperature 130-150C and pressure 5.0-7.0 MPa with further isolation of target product. ^ EFFECT: method ensures obtaining carbamide, labeled by stable isotope 13C, with high output with sufficient simplicity and manufacturability of method and absence of highly toxic and explosive substances. ^ 4 cl, 2 tbl, 14 ex