TREATMENT OF PAIN

摘要

The invention provides an active agent comprising one or more VEGFR2 agonist for use in treating or preventing VEGFR2-mediated non-inflammatory pain. The VEGFR2 agonist may be selected from the VEGFxxxb family of proteins, particularly VEGF165b, soluble VEGF receptors having activity as inhibitors of VEGFR2 antagonists and VEGFxxx isoforms that have the C-terminal hexapeptide corresponding to expression immediately after exon 7, or VEGFxxx isoforms that lack neuropilin binding mediating portions of the amino acid sequence.