发明名称 |
METHOD AND MEANS FOR IDENTIFYING SUBSTANCES WHICH INHIBIT IGE PRODUCTION |
摘要 |
The invention relates to the field of biomedical and pharmacological research, in particular to the area of immunology, allergies and autoimmune diseases. The inventors have shown that SWAP-70 is a higher-level regulator for STAT-6 and BCL-6, the regulator being specific for IgE production in B-cells by amplifying the effect of STAT-6 and antagonizing the effect of BCL-6. The inventors have observed no influence of SWAP-70 on the expression of other genes that are likewise regulated by STAT-6 and/or BCL-6. In summary, it can be concluded that SWAP-70 positively regulates IgE production by shifting the interaction of the two antagonists STAT-6 and BCL-6 with regulatory elements of the IgE gene in favor of the activator STAT-6. Based on said findings, the invention provides a screening method which allows for identifying novel active agents that specifically inhibit IgE production. The substances identified by the method according to the invention are particularly suited for treating IgE-induced allergies and IgE-dependent autoimmune diseases. |
申请公布号 |
CA2796171(A1) |
申请公布日期 |
2011.11.17 |
申请号 |
CA20112796171 |
申请日期 |
2011.04.14 |
申请人 |
JESSBERGER, ROLF;AUDZEVICH, TATSIANA |
发明人 |
JESSBERGER, ROLF;AUDZEVICH, TATSIANA |
分类号 |
G01N33/564;G01N33/50 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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