发明名称 |
Polymeric carrier for delivery of small interfering RNA |
摘要 |
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed. |
申请公布号 |
US8058256(B2) |
申请公布日期 |
2011.11.15 |
申请号 |
US20100691566 |
申请日期 |
2010.01.21 |
申请人 |
KIM WON JONG;KIM SUNG WAN;UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
KIM WON JONG;KIM SUNG WAN |
分类号 |
A61K48/00;A61K38/04;A61K51/00;C07K5/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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