发明名称 |
METHOD FOR POLYMERIZING A SMALL OLIGONUCLEOTIDE, AND USE OF A HIGH-MOLECULAR OLIGONUCLEOTIDE PREPARED BY THE POLYMERIZATION METHOD |
摘要 |
The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method. The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
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申请公布号 |
US2011274930(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
US201013142876 |
申请日期 |
2010.03.02 |
申请人 |
KIM KWANGMEYUNG;KWON IEK CHAN;CHOI KUI WON;LEE SEUNG YOUNG;YOUN IN CHAN;HUH MYUNG SOOK;LEE SO JIN |
发明人 |
KIM KWANGMEYUNG;KWON IEK CHAN;CHOI KUI WON;LEE SEUNG YOUNG;YOUN IN CHAN;HUH MYUNG SOOK;LEE SO JIN |
分类号 |
C07H21/02;B32B5/16;C08G73/04 |
主分类号 |
C07H21/02 |
代理机构 |
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地址 |
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