| 摘要 |
<p>Treatments for conditions involving detrimental activity of the enzyme core 2 GlcNAc - T are provided using compounds of the formula I
wherein
R 1 is H, -OH, C 1-6 alkoxy, -NR 5 R 6 , or Sac 1;
R 2 is H, -OH, C 1-6 alkoxy or Sac 2;
R 3 is H, -OH, C 1-6 alkoxy or Sac 3;
R 4 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl or C 1-6 -alkoxy-C 1-6 -alkyl;
R 5 is H, C 1-6 alkyl or C 1-6 acyl;
R 6 is H, C 1-6 alkyl or C 1-6 acyl;
Sac 1 Sac 2 and Sac 3 are independently selected saccharide moieties; and
Z is a steroid moiety;
or a pharmaceutically acceptable salt, ether or ester form thereof, wherein the condition is an autoimmune condition.</p> |
