发明名称 |
Peripherally delivered glutamatic acid decarboxylase gene therapy for spinal cord injury pain |
摘要 |
The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain. |
申请公布号 |
EP2377882(A1) |
申请公布日期 |
2011.10.19 |
申请号 |
EP20110169442 |
申请日期 |
2005.10.28 |
申请人 |
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;THE UNITED STATES GOVERNMENT AS REPRESENTED BY DEPARTMENT OF VETERAN'S AFFAIRS |
发明人 |
GLORIOSO, JOSEPH C.;FINK, DAVID J.;WOLFE, DARREN;KRISKY, DAVID |
分类号 |
C07K14/435;C12N9/88 |
主分类号 |
C07K14/435 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|