<p>Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.</p>
申请公布号
WO2011123742(A1)
申请公布日期
2011.10.06
申请号
WO2011US30868
申请日期
2011.04.01
申请人
BAYLOR COLLEGE OF MEDICINE;WANG, WEI;SHOHET, JASON;MAWAD, MICHEL;KE, SHI